Anesthesia Safety for Older Adults

How anesthesia can affect the brain health of older adults.
Written and Reviewed by Sherry Bernardo, DNP, MHA, CRNA, APRN
CRNA prepping an older adult for anesthesia by placing tape on eyes
Article Summary
Older adults may have unique health needs that can affect how they respond to anesthesia and surgery. This article explains the steps anesthesia professionals take to reduce risks, manage existing medical conditions, and support safe recovery before, during, and after a procedure. It also provides information to help older adults and their caregivers prepare for surgery and participate in decisions about their care.

Anesthesia and brain health

As we age, our brains can become more sensitive to anesthesia. Your anesthesia professional, such as a Certified Registered Nurse Anesthetist (CRNA), takes special care to keep older adults, and their brains, safe before, during, and after anesthesia. While the risk of anesthesia negatively affecting brain health is rare, it’s important to know about these potential side effects to support your safety and recovery.

When older adults have anesthesia, especially general anesthesia, they are at an increased risk for two brain health concerns: postoperative delirium and postoperative cognitive dysfunction (POCD).

What is postoperative delirium?

Postoperative delirium is a state of confusion that can happen after surgery. You might feel confused, disoriented, have trouble paying attention, or not remember things clearly. The good news is that delirium is usually temporary and often goes away within a few days or weeks. 

What is postoperative cognitive dysfunction (POCD)?

POCD refers to problems with thinking, concentration, and memory skills. After surgery, some older adults notice it takes longer to remember things or think as clearly as they did before. This type of problem can last longer than deliriumsometimes for months or more

What factors increase your risk of delirium or POCD?

Several things can increase the likelihood of these changes. These include both personal and surgery-related factors: 

Personal Factors:  

  • Older age (older than 65 years old)  
  • Existing memory or thinking problems 
  • Poorly controlled conditions such as high blood pressure or diabetes  

Surgery-related Factors:   

  • Longer or more complex procedures 
  • Intensive care unit (ICU) stay after surgery 

What can I do to lower my risk?

many risk factors can be improved before surgery. These include:

  • Increasing exercise and activity to help your body and brain 
  • Managing depression 
  • Controlling your blood pressure 
  • Improving your sleep 
  • Managing your blood sugar, especially if you have diabetes  
  • Avoiding alcohol and drugs 
  • Telling your healthcare team about all the medicines you take, as some medications can cause problems 
  • Treating infections 
  • Eating a healthy, balanced diet 
  • Managing pain appropriately after surgery 
  • Having support from family or friends before and after surgery 

Learn about Anesthesia and Memory Loss.

Frequently Asked Questions

Common questions about anesthesia safety for older adults.

How common are confusion and memory problems after surgery?

Among older adults, about 65% experience some confusion right after surgery. About 10% develop longer-lasting memory or thinking problems. While most patients do just fineit’s something to watch for.

How will my anesthesia professional help prevent delirium or POCD?

Your healthcare team has several strategies to keep your brain safe during and after surgery: 

  • Personalized anesthesia care: The anesthesia professional will choose the safest type of anesthesia for you, and use the smallest amount necessary to keep you safe and comfortable.
  • Close monitoring: Special equipment watches your oxygen levels, blood pressure, and other important signs.
  • Pain management: Good pain control after surgery helps prevent confusion.
  • Early movement: Encouraging activity as soon as it’s safe.
  • Sleep support: Good sleep after surgery is important for your brain to heal.
  • Team coordination: Clear communication with your healthcare team.

What medications should I avoid?

Tell your anesthesia professional about all your medications, as some medicines can increase confusion after surgery, including varieties of allergy, sleep, and anti-anxiety medications. Your healthcare provider may adjust your medications before surgery to help keep you safe. 

What should I watch for after surgery?

It’s normal to feel a little confused or sleepy for a short time after anesthesia. Contact your healthcare team right away if you or a loved one: 

  • Becomes very confused or can’t pay attention 
  • Does not recognize people or places 
  • Has trouble remembering recent events 
  • Feels unusually agitated or restless 
  • Has trouble thinking clearly days after surgery 

How can I help as a caregiver?

If you are helping care for an older adult having surgery: 

  • Ask the healthcare team about risks and prevention strategies 
  • Help orient your loved one or friend to time, place and surroundings 
  • Watch for changes in memory, mood and behavior 
  • Encourage movement, good sleep and pain management 
  • Stay in touch with the healthcare team about how your loved one or friend is doing 

Sources

Berger, Miles MD, PhD*; Schenning, Katie J. MD, MPH†; Brown, Charles H. IV MD, MHS‡; Deiner, Stacie G. MD§; Whittington, Robert A. MD‖; Eckenhoff, Roderic G. MD¶. Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group. Anesthesia & Analgesia 127(6):p 1406-1413, December 2018. | DOI: 10.1213/ANE.0000000000003841 

Peden, Carol J., et al. “Improving perioperative brain health: an expert consensus review of key actions for the perioperative care team.” British Journal of Anesthesia 126.2 (2021): 423-432. 

Scharp, Danielle, et al. “Perioperative Best Practices and Delirium in Patients With Cognitive Impairment.” JAMA Network Open 9.3 (2026): e261515. 

Strøm, Camilla, L. S. Rasmussen, and F. E. Sieber. “Should general anesthesia be avoided in the elderly?.” Anesthesia 69 (2014): 35-44. 

Vacas, Susana, Daniel J. Cole, and Maxime Cannesson. “Cognitive decline associated with anesthesia and surgery in older patients.” Jama 326.9 (2021): 863-864. 

Disclaimer: The information on this page is for general educational and informational purposes only and does not constitute medical advice or a recommendation for any specific anesthesia technique, drug, or treatment. Users should consult a qualified medical professional before making any decisions regarding anesthesia care. For complete terms, see our Terms of Use.


 

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